Tragedy has struck Pierce Brosnan for a second time.
The James Bond actor has lost his daughter Charlotte to the same disease that claimed his first wife 22 years ago.
Brosnan was said to be "deeply in mourning" after Charlotte died on Friday from ovarian cancer aged 42.
She had been struggling with the disease for three years.
In a statement released to People magazine, Brosnan said: "On June 28 at 2 pm my darling daughter Charlotte Emily passed on to eternal life, having succumbed to ovarian cancer.
"She was surrounded by her husband, Alex, children Isabella and Lucas and brothers Christopher and Sean.
"Charlotte fought her cancer with grace and humanity, courage and dignity. Our hearts are heavy with the loss of our beautiful dear girl. We pray for her and that the cure for this wretched disease will be close at hand soon. We thank everyone for their heartfelt condolences."
Charlotte was adopted by Brosnan in 1986 after her biological father, Cassandra's first husband, Dermot Harris, died.
She was nine when Brosnan and her mother married in 1980.
Brosnan, who remarried in 2001, said recently that he was still deeply affected by his first wife's death. "I went through it all, very publicly. Such things draw a mark across your heart and it's always a part of your life. To watch someone you love have their life eaten away - bit by bit, by this insidious and horrid disease - becomes an indelible part of your psyche," he told UK newspaper Mail on Sunday.