"I don't have any interest in acting anymore," Baldwin, 51, told Men's Journal in an interview for its December issue.
Baldwin, best-known for his Emmy-award winning role in the NBC comedy 30 Rock and the man chosen to co-host the 2010 Oscar ceremony, added: "Movies are a part of my past. It's been 30 years. I'm not young, but I have time to do something else".
Baldwin began a television acting career in the 1980s and has filmed scores of movies, including the 1988 cult classic Beetlejuice. He was nominated for an Academy Award for his role in the 2003 film The Cooler and stars in the upcoming movie It's Complicated with Meryl Streep and his Oscar co-host Steve Martin.
Men's Journal quoted Baldwin as saying it was "pretty much it for him" after 30 Rock, "in a couple of years or so". He told Playboy Magazine this year he was "done" with his career in 2012 and would retire at 30 Rock's wrap party.
"I consider my entire movie career a complete failure," he told Men's Journal. "The goal of movie-making is to star in a film where your performance drives the film, and the film is either a soaring critical or commercial success, and I never had that."
Baldwin said the 1990 action film The Hunt for Red October, in which he starred and which made more than $200 million worldwide, was successful because it was based on a popular Tom Clancy novel.
"And now, the movies I've been in, I never give them a moment's thought. Every movie I've ever been in, I just avoid," he said.
Baldwin has expressed interest in politics in the past but did not say in the interview what he intended to do should he quit acting.