In-form all-rounder James Faulkner has been ruled out of Australia's tour to South Africa while batsman Shaun Marsh is in grave doubt with a calf strain.
Australia's injury-free summer has come to a grinding halt on the eve of the Test squad's departure for the showdown with the top-ranked Proteas.
Faulkner will have arthroscopic surgery on his knee on Tuesday, Marsh will stay in Perth for treatment on his calf instead of getting on the plane to Johannesburg and paceman Jackson Bird is battling a back problem.
"James injured his knee during the Australia Day one-day international in Adelaide," team physiotherapist Alex Kountouris said.
"He has had subsequent scans and was reviewed by Cricket Australia's medical team and a knee specialist, and will require arthroscopic surgery on Tuesday.
"James' exact rehab plan and return to training and playing will be determined after surgery but unfortunately for him, he will not be available for the upcoming Test tour of South Africa. We are hopeful that he will recover in time to play the Twenty 20 games on that tour and take part in the ICC World Twenty20."
Bird, who is nursing a jarred back, is no certainty to tour either. Bird, who missed the first half of his season with a stress fracture of the back suffered in England last year, was pulled out of a Futures League game in Brisbane this week.
- Sydney Morning Herald