World No.4 Jason Day withdrew from the World Golf Championship's Cadillac Championship with a thumb injury before starting his opening round.
Day was set to start with marquee pairing Phil Mickelson and Rory McIlroy at Trump National Doral but pulled the pin with a sore left thumb before getting underway.
Fresh from winning the WGC Match Play Championship two weeks ago he was expected to contend heavily but did not want to risk further injury before next month's Masters tournament.
"My left thumb was bothering me at the Match Play Championship and the pain continued here this week," Day said.
"I had an MRI yesterday here in Miami which fortunately was negative, but the doctor prescribed rest.
"My plan is to rest for a couple of weeks. I'm sorry to miss the Cadillac Championship, it looks like it's going to be a great event."
Day is due to play the Arnold Palmer Invitational in two weeks time before lining up at the Masters from April 10-13.
Adam Scott, Scott Hend and Brett Rumford are now the only remaining Australians in the elite event at Doral.
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