Wales lock Alun-Wyn Jones and flanker Josh Turnbull will miss the rest of the autumn rugby series because of their injuries in the 26-12 loss to Argentina last weekend.
Jones popped his left shoulder and was replaced in the first half, while Turnbull damaged knee ligaments. The Welsh Rugby Union said they will miss the test against Samoa at Millennium on Friday, followed by matches against New Zealand and Australia.
Flanker Ryan Jones and centre Ashley Beck are expected to be fit to face Samoa, while centre Jamie Roberts was still recovering from being concussed in the first half against the Pumas.
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