The entrance to Wintec's Rotokauri campus will change from Avalon Dr to Akoranga Rd from Monday.
Forty new public car parking spaces will also be available on Akoranga Road.
Signage directing visitors to the campus entrance will be visible from the Avalon Dr section of the Waikato Expressway.
Wintec Chief Executive Mark Flowers said the change in road was part of a number of changes at the campus.
"The public will see some changes to our Rotokauri campus over the coming months, in particular the construction of the new Engineering and Trades facility which begins next year. This campus is in the heart of the city's industrial area and we're keen to develop better connections with this community."
"Through our student training restaurant Windows, our sustainable research facility and industry training facilities, we already enjoy many visitors to the campus. I'd hope to see more people enjoying the campus as a result of the new entrance, as it will be much safer to access than the current Avalon Drive entry."
From 6.00am next Monday, the Akoranga Road entrance will be the only access point to the Rotokauri campus, with the Avalon Drive entrance to be closed permanently.
Wintec opened its campus on Avalon Drive in 1995.
It is home to the School of Trades, School of Sport and Exercise Science and Centre for Hospitality, student training restaurant Windows, a student hub, the Centre for Industry Training and a student village and research facility.
Sports House, which is occupied by Sport Waikato, is also based on the Rotokauri campus.
Wintec's other campuses are located in the Hamilton's central city, the Hamilton Gardens, Te Kuiti, Thames and Otorohanga.