Drug found to cure Ebola in monkeys raises hope

LENNY BERNSTEIN, ABBY OHLHEISER AND ABBY PHILLIP
Last updated 15:27, August 30 2014
GRIM JOB: Health workers wearing protective clothing prepare themselves before to carrying an abandoned dead body presenting with Ebola symptoms at Duwala market in Monrovia.
Reuters

GRIM JOB: Health workers wearing protective clothing prepare themselves before to carrying an abandoned dead body presenting with Ebola symptoms at Duwala market in Monrovia.

As the Ebola outbreak spread to a fifth African country, researchers announced that the experimental drug pressed into emergency use in recent weeks had cured a group of 18 monkeys of the deadly disease, including some that didn't receive the treatment for five days after they were injected with the virus.

The research raised new hope for the eventual use of the cocktail of monoclonal antibodies against Ebola, which has no cure or vaccine. It has been fatal to more than half of the 3069 people who have acquired the virus in Liberia, Guinea, Sierra Leone, Nigeria, and now Senegal, which confirmed its first case on Friday (local time).

The research unveiled on Friday in the online version of the journal Nature is "a huge step forward", said Thomas Geisbert, a professor at the University of Texas Medical Branch at Galveston, who has conducted similar research on the lethal Marburg virus and reviewed the Ebola study for Nature. "It's very, very hard for me to believe that this would not have substantial utility in treating human disease."

The drug, ZMapp, "was able to reverse severe [Ebola] disease . . . leading to full recovery of all treated" non-human primates within 28 days after they were infected, the researchers wrote.

The treatment has not been tested on humans, although it was given on an emergency basis to seven people who fell ill in recent weeks, including two American missionaries who recovered. Of the seven who received the drug, two have died - an elderly Spanish priest and a Liberian doctor. Two other doctors in Liberia and a British nurse are still being treated. But it is impossible to determine the drug's impact on a small sample of people who became infected at different times and received their care under differing circumstances.

The small supply of the drug, perhaps 20 doses, is exhausted, according to Mapp Biopharmaceutical, the tiny San Diego company that developed it.

In a telephone news conference, Gary Kobinger of Canada's Public Health Agency, one of the authors of the newly released paper, said human subjects should receive three doses of the drug to maximize its effectiveness. He estimated that Kentucky BioProcessing, the company that manufactures the drug in tobacco plants, could produce 20 to 40 doses a month once it is working at full speed - a small fraction of the number that may be needed.

Kobinger said he thinks additional doses should be available for humans by the summer of 2015.

But David Howard, a spokesman for Reynolds American Services, which owns Kentucky BioProcessing, said in an email: "Any estimate of output or capacity regarding production of ZMapp would be pure speculation at this time, since what constitutes a human dose hasn't been determined yet. The important issue right now is to focus on the need to proceed through clinical and production process development steps. Until these steps are completed, we can't know things like dose size or dose frequency."

Asked whether his research shows that ZMapp will work on people, Kobinger said: "I think it strongly supports that concept, but it's not proven." Geisbert, the professor, noted that the rhesus macaques studied were given proportionately much larger doses of Ebola than most infected humans receive, and the drug was injected directly into their bodies, not absorbed through the skin.

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As a result, he said, healing all 18, especially after some had become severely ill with the hemorrhagic disease, means the drug shows promise.

The researchers did not test ZMapp on the highly lethal Zaire strain of the Ebola virus that is spreading across West Africa, but they said the version of the virus they used is similar and the treatment should work on it. Kobinger said the monkeys tested appear to be completely healthy, with no side effects that other drugs had caused. Three infected monkeys that were not treated died within eight days.

The study marked the first time that test subjects were effectively treated five days after acquiring the infection. Geisbert and another group of researchers reported last week that they had used a different drug to successfully treat monkeys three days after the animals were infected with Marburg.

On Thursday, US government researchers, in collaboration with British drugmaker GlaxoSmithKline, announced that they will begin human trials of an experimental Ebola vaccine next week at the National Institutes of Health in Bethesda, Maryland. Officials said they want to rush the drug to health workers and others at risk in West Africa.

More than 1500 people have died in the worst Ebola outbreak in history, according to the World Health Organization, which predicts that the current epidemic could ultimately total 20,000 cases. (A handful of cases, which officials have said is a separate outbreak, also have emerged in Congo.)

Senegal's health minister, Awa Marie Coll-Seck, said the Ebola patient discovered there - a Guinean national who traveled to Senegal - has been put in isolation.

As the outbreak worsened in West Africa, Senegal had taken aggressive measures to prevent the virus from spreading into the country. Last week, Senegal closed its borders with neighboring Guinea, preventing flights headed to Guinea, Sierra Leone or Liberia from touching down in Senegal, a major travel hub for the region.

 - The Washington Post

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