Wheelchair-bound man beaten in Sydney

A man in a wheelchair has been punched in the face, stomped on and hit on the head with metal bars at a train station in Sydney's west.

The 35-year-old Canadian national was trying to leave Mt Druitt station when two males began verbally intimidating him on Tuesday night, police say.

As he entered the lift, one of the attackers punched him in the face, causing him to fall onto the ground.

The pair then stomped on his body, tried to take his chair and belongings, and struck his head with metal bars.

They allegedly returned a number of times to attack the man again with the bars, but were eventually arrested by police after a foot chase.

A 17-year-old boy is assisting with inquiries at Mt Druitt police station.

A search is under way for a second male, described as being of Pacific Islander appearance and aged in his teens.

The victim has been taken to Nepean Hospital in a serious condition and will require surgery for severe cuts to his head and a depressed fracture to his skull.

- AAP